All products on this site are for In-Vitro Research, Development use only. Products are Not for Human consumption of any kind. All products on this site are for In-Vitro Research, Development use only. Products are Not for Human consumption of any kind.
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Buy Pentapeptide-18 Leuphasyl

Buy Pentapeptide-18 LeuphasylBuy Pentapeptide-18 Leuphasyl for research today. We only supply the best quality research chemicals. So, for those in the research industry who want to buy Pentapeptide-18 Leuphasyl click here now for $230.00!

Pentapeptide-18 or Leuphasyl is a research peptide that can have a positive effect on reducing wrinkles and improving skin firmness.

What is Pentapeptide-18 Leuphasyl?

Pentapeptide-18 Leuphasylins is a hormone that is used to increase skin firmness and reduce wrinkles.

This medicine is available only with your doctor’s prescription. Use Pentapeptide-18 Leuphasylins exactly as your doctor tells you to. Do not take in larger amounts, or indifferent amounts, or for longer than your doctor tells you to. If you are pregnant or breastfeeding, ask your doctor before you use Pentapeptide-18 Leuphasylins.

What is SNAP-8 Peptide?

This medicine may cause addiction. People who become addicted to Pentapeptide-18 Leuphasylins often abuse alcohol, illegal drugs, or street drugs. Some people become addicted to Pentapeptide-18 Leuphasylins even if they take it as directed. Addiction can happen right after you start taking Pentapeptide-18 Leuphasylins, even if you have been using it for a long time. You may stop taking Pentapeptide-18 Leuphasylins and go through withdrawal symptoms. Call your doctor if you are in withdrawal from Pentapeptide-18 Leuphasylins.

Pentapeptide-18 Leuphasylins is sometimes used with other medicines to treat skin problems.

Pentapeptide-18 Leuphasylins Side Effects

This medicine may cause dizziness, drowsiness, fainting, or lightheadedness. It may also cause you to fall asleep suddenly. Talk to your doctor before driving, using machines, or doing anything else that could be dangerous if you are drowsy. Do not use this medicine for at least 4 hours before bedtime.

Pentapeptide-18 Leuphasylins may pass into breast milk. Tell your doctor if you are breastfeeding a baby. Pentapeptide-18 Leuphasylins is not safe for use during pregnancy. Do not take Pentapeptide-18 Leuphasylins without first talking to your doctor if you are pregnant or may be pregnant.

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PE-22-28 For Sale

 

PE-22-28 For SalePE-22-28 for sale here today for research and education use only. If you are in the research trade and want to buy PE-22-28 click here now.

PE-22-28 is a research peptide that is being tested to improve memory, mood, and learning. It is not for human consumption. The hopeful news is it is hoped one day to help in treating Alzheimer’s, and stroke recovery.

What is PE-22-28?

Alzheimer’s is the third leading cause of death after heart disease and cancer. Currently there is no cure for the disease. The drug PE-22-28  is a new generation of treatments for Alzheimer’s.  It has been demonstrated to be better than the drugs that have been around for a long time. At present, there are two Alzheimer’s drugs on the market: Aricept, by Pfizer, and Exelon, by Forest Pharmaceuticals. They all work in different ways. Exelon is based on stimulation of the brain, while Aricept works to reduce the production of proteins called beta-amyloid that build up in the brain.

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Alzheimer’s involves a build-up of beta-amyloid protein, which can cause damage to brain cells, eventually leading to memory loss and cognitive decline.

As more and more people are diagnosed with the disease, many researchers are focused on finding a cure. It is estimated that nearly 6 million Americans have Alzheimer’s, and those numbers are expected to rise.

Alzheimer’s is a disease that affects people’s memories, thinking, behavior, and physical appearance. The majority of people with the disease are over the age of 65. A diagnosis of Alzheimer’s can also be made at any age. With advances in research, medical tests are now available to detect the disease, before symptoms appear. However, diagnosis is only possible after a diagnosis is made through an examination of tissue under a microscope, such as by a neuropathologist.

Research is moving in many directions

Drug Research: Most Alzheimer’s drugs attempt to inhibit the formation of amyloid protein. Drugs may attempt to stop the amyloid proteins from clumping together and forming plaque. The amyloid proteins cause damage to brain cells and interfere with brain functions.

Vaccines

These are a new type of drug being researched. Instead of working with existing amyloid proteins, researchers are designing antibodies (synthetic proteins designed to identify and kill viruses and bacteria) that match the different types of amyloid proteins. The antibodies are given as shots, directly into the blood. They will act like a drug by tagging the amyloid protein and getting them to target the brain to kill them.

Gene Therapy

A third way of treating Alzheimer’s is gene therapy. The goal of this type of treatment is to make changes in the genes to keep the brain working.

The National Institute on Aging, part of the National Institutes of Health, is currently funding nine Alzheimer’s disease drug trials. The trials are expected to be completed in 2013, but it may take up to three years to publish the results. If a drug is successful, it could help many people.

Currently, most treatments for Alzheimer’s focus on either slowing the progression of the disease or stabilizing patients’ mental abilities.

For more information on research to find a cure for Alzheimer’s, please visit the Alzheimer’s Association’s website.

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Buy Melanostatin DM

 Buy Melanostatin DM Buy Melanostatin DM 200mg for education and research only. If you are in the research community and want the best quality Melanotan and buy Melanostatin DM  make sure you click here now!

What is Melanostatin DM?

Melanostatin DM, also known as melanotropin release-inhibiting factor (MIF or MRIF) is a peptide that inhibits the release of melanotropin and melanosin from the pituitary gland and other cells by binding to a specific membrane-associated receptor. Melanotropin is the naturally occurring ligand for the MIF receptor. MIF was first identified in the media of the T hybridoma MIF I and later confirmed in the supernatants of B16 melanoma and other tumor cell lines by a series of biophysical and biochemical assays that characterized it as a novel cytokine.

How does Melanostatin DM Works?

In the body, MIF has the function of an inflammatory cytokine (1-4) and is produced in many cell types such as activated macrophages, activated lymphocytes, activated mast cells, activated osteoclasts, activated endothelial cells, activated glial cells, activated keratinocytes and activated platelets. Some of these cells produce MIF constitutively or after stimulation. Most of these cells produce MIF at low concentrations. An increasing number of cells release MIF after activation.

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MIF is not related to the ciliary neurotrophic factor (CNTF), interleukin 1 (IL1), tumor necrosis factor (TNF) or interleukin 4 (IL4), which are also known as neurotrophic factors, proinflammatory cytokines, or TH2 lymphocyte cytokines. MIF is closely related to interleukin 1 beta (IL1β) and interleukin 6 (IL6) in terms of amino acid sequence and biochemical activity. Unlike IL1, MIF is a broad-acting immunostimulant. MIF is also closely related to interleukin 2 (IL2) (14) and a number of hematopoietic cytokines including tumor necrosis factor-α (TNF-α).

What Melanostatin DM Can Do?

MIF is a multifunctional cytokine that belongs to the interleukin-1 cytokine family. MIF is widely distributed in cells and body fluids such as tears, saliva, cerebrospinal fluid, blood, serum, and urine. When human leukocytes are activated by various stimulants, MIF is secreted by the leukocytes. For instance, when blood cells such as leukocytes, monocytes, macrophages, and polymorphonuclear leukocytes (neutrophils, eosinophils, and basophils) are activated, MIF is released from the cells.

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The secretion of MIF from neutrophils and monocytes after stimulation with endotoxin or N-formyl-methionyl-leucyl-phenylalanine is also reported in the literature. Studies show that MIF is expressed in monocytes, monocyte-derived macrophages, neutrophils, eosinophils, and NK cells.

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Studies also demonstrate that the secretion of MIF is associated with many immune and inflammatory disorders, including various infectious diseases, inflammatory conditions, cancer, immunological disorders, transplant rejection, bone diseases, and neurological diseases. The effects of MIF on inflammatory conditions and tumor cells also include cell proliferation, angiogenesis, cell migration and invasion, adhesion, and metastasis.

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A number of studies on the effects of MIF on immune and inflammatory disorders, tumor cells, inflammatory diseases, and other conditions have been published (33-37). For example, it is reported that the production of MIF is increased in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Furthermore, patients with autoimmune diabetes mellitus (DM) have increased levels of MIF. It has also been reported that MIF levels are increased in sera and synovial fluid of patients with juvenile RA and that the serum level of MIF is significantly higher in a group of patients with RA than in a healthy control group.

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It has also been reported that administration of a neutralizing antibody to MIF prevents joint erosion in collagen-induced arthritis (CIA) mice and that administration of a recombinant adenovirus containing an antisense RNA against MIF inhibits synovial hyperplasia in rats with adjuvant arthritis. It is also reported that injection of MIF into the joints of arthritis-susceptible mice induces joint swelling.

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MIF has been reported to play a role in various aspects of chronic pain and to modulate the sensitivity of nociceptive neurons. It is also reported that inhibition of MIF synthesis may be useful for treating inflammatory and neuropathic pain.

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It is also reported that administration of anti-MIF antibody reduces the severity of skin lesions and decreases the incidence of lung metastasis in an experiment in which an adenocarcinoma is transferred into the footpad of mice.

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It is further reported that MIF induces the expression of matrix metalloproteinases (MMPs) in cultured human prostate cells and that MIF is a potent mitogen for prostate cells. It is also reported that IL-1α, IL-1β, IL-4, IL-6, IL-10, TNF-α, and interferon-γ (IFN-γ) increase the production of MIF by primary cultures of monocytes. Furthermore, MIF stimulates the secretion of VEGF by retinal epithelial cells.

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It is further reported that MIF causes proliferation of cells (e.g. B16 melanoma cells) and angiogenesis and regulates the migration and invasion of cancer cells. It is also reported that MIF enhances cell adhesion of human colon cancer cells, fibrosarcoma cells, and gastric cancer cells. Studies report that MIF stimulates metastasis in experimental models of breast and colon cancer. It is also reported that MIF suppresses tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in A375 melanoma cells.

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Buy Hexarelin Acetate

Buy Hexarelin Acetate here today for the best prices onlineBuy Hexarelin Acetate. Hexarelin is a research peptide that is still being investigated. It is not for human consumption.

What is Hexarelin used for?

Hexarelin is a synthetic analogue of ghrelin that shows benefit in heart disease and cardiac ischemia, protecting the heart following a heart attack. Research has shown that Hexarelin also protects skeletal muscle against wasting and improves cholesterol and triglyceride levels. A recently completed phase II human trial in heart failure patients revealed that Hexarelin protected the heart following a heart attack and the results from this trial are promising.

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In 2011, a multi-center randomized double-blinded, placebo-controlled, dose-escalating study of 30 healthy adult volunteers showed that Hexarelin reduces markers of the aging process (e.g., telomere length, interleukin-6, and C-reactive protein). These effects were dose-dependent.

Is hexarelin a GHRH?

Hexarelin has been shown to reduce insulin resistance, reduce blood pressure, lower cholesterol and triglycerides, reduce adipose tissue inflammation, increase energy expenditure, and reduce the risk of obesity in clinical trials. It has been shown to produce weight loss in clinical trials.

Hexarelin is being developed by Gensign Health in collaboration with Pronos Group (Moss, England) as a potential treatment for cardiovascular disease and other conditions where a sustained release formulation would be advantageous.

What are Hexarelin Benefits?

Cardiovascular disease is a major health problem in the western world. Chronic cardiovascular disease, often seen in combination with diabetes, is the major cause of death in patients with Type 2 Diabetes (T2D).

Ghrelin is a peptide that is predominantly secreted by the stomach and is implicated in metabolic regulation. In its active form, ghrelin has been shown to increase appetite and food intake in a number of animal studies. In humans, plasma levels of ghrelin are elevated following meal ingestion. Ghrelin also has effects on cardiovascular function. In experimental animals, ghrelin is shown to reduce cardiac contractility and blood pressure and to stimulate vasodilation. Chronic administration of ghrelin in rats, induces a decrease in blood pressure and increases endothelium-dependent vasodilation.

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Clinical data have shown that ghrelin and its analogues are associated with favourable effects on body weight and weight gain, in obese and overweight subjects. This clinical benefit is independent of the food that the individual consumes. Studies have also shown that ghrelin may protect the heart following a heart attack and may promote cardiac recovery.

In the setting of ischemia, ghrelin has been shown to reduce infarct size, limit remodeling and improve ejection fraction. This ability to protect the heart during an episode of acute ischemia has implications for the treatment of ischaemic heart disease. Ghrelin also has beneficial effects on the cardiovascular system in individuals with Type 2 Diabetes (T2D). For example, chronic administration of ghrelin increases insulin sensitivity in healthy volunteers, animal models, and patients with T2D. Ghrelin is also shown to increase fat oxidation and reduce systemic lipid levels in patients with T2D.

Development of Hexarelin

A synthetic analog of ghrelin, Hexarelin (hexarelin and \[D-Lys-6\]-GHRP-6), has been shown to be an effective and safe weight loss agent in obese adults. Two-phase III randomized, double-blind, placebo-controlled, multi-center trials have been completed which demonstrated the efficacy of Hexarelin for the treatment of overweight and obese adults.

The phase III trials met their primary endpoints demonstrating that Hexarelin causes greater weight loss than placebo at 12 and 24 weeks. These results were obtained after approximately 11 and 17 days of treatment. These trials also demonstrated a reduction in total fat mass and fat mass in the legs. Although there was no difference between groups in body weight after 12 weeks, patients treated with Hexarelin at the lower doses were less likely to gain weight and remained in a normal weight range.

The primary results of these studies were presented at the 54th Annual Meeting of the European Association for the Study of Diabetes in Munich, Germany.

The safety of Hexarelin was also demonstrated in these trials. These trials showed that Hexarelin did not produce any adverse effects that would lead to discontinuation of the treatment. The most commonly reported side effect in both trials was dizziness (a decrease in blood pressure) that occurred more frequently in the Hexarelin treated groups. Other reported side effects included nausea, abdominal discomfort, headache, and gastroenteritis.

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Results from a recently completed randomized, double-blind, placebo-controlled, dose-escalating trial in a heart failure patient population (NCT00976562) indicated that Hexarelin improved lipid and glucose parameters, reduced the risk of death and hospitalization for heart failure, and reduced the risk of dying or needing a transplant.

The study enrolled 102 patients, of whom 26 were included in the per protocol analysis.

A total of 22 patients (85%) received the higher Hexarelin dose of 1.25 mcg/kg/min and 4 patients (15%) received the lower dose of 0.625 mcg/kg/min. The primary endpoint was changed in insulin resistance. Hexarelin had a positive effect on fasting blood glucose (mean reduction from baseline in Hexarelin treated patients was 0.45 mmol/L), insulin resistance (the homeostasis model assessment insulin resistance, HOMA-IR), and the fasting plasma triglycerides (the mean change from baseline for this parameter was -6.5%). Furthermore, Hexarelin improved the metabolic parameters of the cholesterol fraction and low density lipoprotein (LDL).

The most common side effects in this trial were nausea and dizziness (which occurred in the majority of patients).

Gensign Health is now planning to begin phase III clinical trials in patients with T2D.

Safety and quality research peptides for sale

Hexarelin is manufactured in-house by Gensign Health and all products are manufactured with GMP standards in place.

Hexarelin has been approved by the FDA as an investigational new drug (IND) for the treatment of over weight/obese patients. It is the only synthetic derivative of ghrelin which has been approved for the treatment of obesity and is in the final stages of testing for the treatment of heart disease.

Hexarelin has been marketed in Japan, Germany and the UK for the treatment of obesity.

Hexarelin has been manufactured in GMP conditions by Gensign Health, UK and is packaged in foil pouches and glass vials.

All products on this site are for In-Vitro Research, Development use only. Products are Not for Human consumption of any kind.