All products on this site are for In-Vitro Research, Development use only. Products are Not for Human consumption of any kind. All products on this site are for In-Vitro Research, Development use only. Products are Not for Human consumption of any kind.
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B7-33 Peptide For Sale

B7-33 Peptide For Sale here for the competitive price of $70.00!B7-33 Peptide For Sale We supply the very best research products including B7-33 peptide. Buy B7-33 here now and you will not be disappointed! All of our research products are safe and made in the USA.

What is B7-33 Peptide?

B7-33 is a soluble research peptide taken from the larger, naturally occurring protein H2-relaxin. It is impacting the musculoskeletal system, cardiovascular system, and reproduction. B7-33 retains the anti-fibrotic properties of relaxin without enhancing cAMP production.

B7-33 is more stable and therefore is preferred. It is being investigated as an anti-fibrotic agent in preclinical animal models of liver disease, systemic sclerosis, idiopathic pulmonary fibrosis, and other fibrotic conditions. There are currently five trials of B7-33 in clinical trials for different liver conditions. B7-33 has shown promise in preclinical models of liver disease and the next challenge is to establish how it will perform in human trials.

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If you are searching for B7-33 Peptide For Sale check out this link here now! Our B7-33 has the certificate of analysis and is safe and prude for all of your research needs.

How Does B7-33 Work?

B7-33 will have to show efficacy in treating liver fibrosis. It has not been formally tested in this context and it is likely that the disease is being challenged in ways it is not challenged in other liver diseases. The majority of liver disease is due to alcohol and other drugs rather than viral hepatitis and therefore the liver biology is completely different. The fibrotic process in chronic alcoholics appears to differ from that seen in viral hepatitis.

B7-33 Mechanism of action

The mechanisms by which B7-33 reduces fibrosis in models of chronic alcoholism, which are not associated with viral hepatitis, are unknown but may be related to the anti-inflammatory action of B7-33 and reduction of the TGF-β signaling pathway. Furthermore, in alcoholic models of liver disease, B7-33 seems to attenuate liver regeneration ([@B34]), which may be important in preventing a second hepatectomy. Thus, B7-33 is likely to be efficacious in alcoholic liver disease and probably in idiopathic liver fibrosis but will be tested in other disease states.

B7-33 Benefits

B7-33 also attenuates inflammation and oxidative stress. It does not appear to promote hepatic insulin resistance and it is safe in humans. These latter properties make it a potentially attractive alternative to anti-inflammatory drugs such as corticosteroids. It is important to note that the preclinical safety profile of B7-33, which is well established, is likely to be reproduced in humans.

B7-33 Trials

Other therapies in preclinical development for liver fibrosis include galectin-3 which mediates fibrosis and is an interesting therapeutic target since it acts as a ligand for E-cadherin on liver cells. There is one clinical trial in clinical trial in liver fibrosis with a galectin-3 antagonist, RG7213 but it is not known if the compound will reach clinical efficacy. Other therapies targeting inflammation include methotrexate, tetracycline derivatives, and the non-nucleoside antibiotic, doxycycline.

There are no clinical trials with either of these compounds for the treatment of liver fibrosis but the tetracycline derivatives are being evaluated for non-alcoholic steatohepatitis (NASH) in a clinical trial. Another potentially interesting therapy is metformin which decreases the liver injury and fibrosis induced by bile duct ligation and CCl~4~ in mice. It is hoped that further development of this drug will yield a better tolerated and effective therapy.

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B7-33 Peptide for Research Conclusion

A substantial body of preclinical evidence demonstrates that liver fibrosis can be reversed and that the fibrosis is associated with a profibrogenic T-cell population. There are several drugs in development, targeting the fibrogenic T-cell and/or profibrogenic cytokine pathways, for this indication. None are yet in clinical use but some may be in the future. We await the outcome of the first clinical trial in NASH in a couple of years. If the drug has efficacy and safety profile in this condition then it may transform the management of NASH and liver fibrosis. In time, these findings may apply to other liver diseases. A recent report demonstrated that a small molecule that targets the T-cell receptor on T-cell subpopulations prevented fibrosis in several mouse models of fibrosis and the authors called for the development of new molecules that target similar cellular pathways.

 

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Gonadorelin For Sale

Gonadorelin For Sale here today for educational and research use only.Gonadorelin For Sale

Is Gonadorelin a peptide?

Gonadorelin is a research peptide that is the same as gonadotropin-releasing hormone (GnRH) that is naturally released from the hypothalamus gland. GnRH causes the pituitary gland to release other hormones (luteinizing hormone [LH] and follicle-stimulating hormone [FSH]). LH and FSH control development in children and fertility in adults. Gonadorelin helps fertility and helps with menopausal symptoms. It is used for women who have low estrogen levels, have a history of multiple abortions, and have not responded to previous hormone treatments.

Gonadorelin For sale as:

For more information about the medication, see PRECAUTIONS: PRECAUTIONS OF KNOWN EFFECTS, SPECIAL SENSITIVITY (ADVERSE REACTIONS), DRUG INTERACTIONS (ADVERSE REACTIONS), DRUG SIDE EFFECTS, and DOSAGE AND ADMINISTRATION.

How do you administer Gonadorelin?

For an oral tablet, an injectable, a topical ointment, or a topical vaginal ring, see FDA Product Information on Contraceptives and Hormone Replacement Therapy.

Tablets, Oral Solution, or Gel

Do not use it in pregnancy or during lactation. Female patients of childbearing potential should use effective contraception during treatment with this medicine and for at least 2 months after the last dose. Do not use it in children.

Gonadorelin Side Effects?

Drugs used in the treatment of endometriosis or polycystic ovary syndrome may cause serious adverse reactions when used with gonadorelin.

ADVERSE REACTIONS

Adverse reactions have been reported. Serious adverse reactions may be life-threatening and can include: blood clots, stroke, cardiovascular problems, and a condition called tumor lysis syndrome. Consult your doctor for more information.

PRECAUTIONS

Pregnancy

If a woman is planning to become pregnant or is pregnant, gonadorelin should be used only when clearly needed and strictly according to the instructions provided by your doctor. The safety of gonadorelin in pregnancy is not known. If used in a woman who is pregnant, gonadorelin may cause an abortion. Gonadorelin should be used with caution if there is a risk of miscarriage (loss of early pregnancy or spontaneous abortions). Gonadorelin is not indicated for the treatment of ovulation disorders or menstrual disorders. It is contraindicated for women with active, severe systemic lupus erythematosus, or when gonadorelin is used as a contraceptive.

Severe hypersensitivity to this drug has been reported. A severe allergic reaction, e.g., anaphylaxis, occurs in less than 1% of patients receiving gonadorelin. Closely monitor patients for symptoms of hypersensitivity during therapy with gonadorelin. Discontinue gonadorelin therapy if an allergic reaction occurs. Injections should be given using medical facilities equipped to deal with anaphylactic reactions.

Contraceptive Effects

Gonadorelin should be used to support fertility in a natural cycle only. Do not use it to prevent pregnancy (contraception). It should be used with caution in women of childbearing potential who do not wish to become pregnant. If you are a woman of childbearing potential (including adolescents), plan your pregnancy carefully. Do not assume that you will be pregnant because you are being treated with this drug. Consult your doctor if you are not certain of your pregnancy status (See PRECAUTIONS).

Do not use an injectable solution of gonadorelin for injection in women who are or plan to become pregnant. Gonadorelin is used only to support fertility. Do not use it to prevent pregnancy (contraception). It should be used with caution in women of childbearing potential who do not wish to become pregnant. If you are a woman of childbearing potential (including adolescents), plan your pregnancy carefully. Do not assume that you will be pregnant because you are being treated with this drug.

Ovulation Disorder

Use gonadorelin only to help women ovulate or to induce ovulation. Do not use to prevent pregnancy (contraception). Do not use this drug to support ovulation in women whose ovulation is not controlled by medications. If you are being treated for an ovulation disorder, you should follow your doctor’s instructions carefully. Do not increase the frequency of your menstrual periods.

Is there a High Risk of a Heart Attack?

Gonadorelin should be used only to help support fertility in women at high risk for a heart attack or who have a history of heart disease. Gonadorelin should be used with caution in women with a history of a previous myocardial infarction, angina, coronary bypass surgery, angioplasty, or stroke. Do not use gonadorelin in the following conditions:

  • Uncontrolled hypertension,
  • Myocarditis or cardiomyopathy (in patients with previous heart disease),
  • Sudden, unexplained, severe weakness,
  • Any disease that may lead to sudden cardiac arrest (e.g., ventricular tachycardia or cardiac arrest).

Gonadorelin For Sale and Important Safety Information

Interactions:

Do not use in combination with GnRH agonists, other gonadotropin-releasing hormones, GnRH analogs, or GnRH-receptor antagonists. The use of GnRH agonists and analogs, and GnRH antagonists may increase the risk of bone loss in women taking gonadorelin.

Caution is advised in patients with a history of diabetes, hypertension, cardiovascular disease, coronary disease, or in those with hyperlipidemia or a tendency to hyperlipidemia.

Use caution in patients with a history of heart disease or arrhythmias.

Take care when giving a dose of gonadorelin subcutaneously in women of childbearing potential.

Use caution in elderly patients, patients with a history of a recent heart attack or stroke.

Do not administer to women in labor, those with risk factors for the acute coronary syndrome, or patients with myocarditis, pericarditis, or unexplained prolonged QTc interval.

Take care with gonadorelin in patients with risk factors for cardiovascular disease (e.g., hypertension, hyperlipidemia), or a history of cardiovascular disease (e.g., coronary artery disease, myocardial infarction, angina, stroke, and transient ischemic attack).

Gonadorelin For Sale for research use only and is not for use on humans.

All products on this site are for In-Vitro Research, Development use only. Products are Not for Human consumption of any kind.