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WHAT IS IGF-1?
The Insulin-like Growth Factor (IGF-1) is one of the endocrine hormones that is produced in the liver. The release of this hormone increases in the presence of Human Growth Hormone. Numerous cells throughout the muscles of the human body are responsible for producing and secreting IGF-1.
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These cells include the liver, spleen, skeletal muscles, heart, lungs, skin, testes and thyroid gland. IGF-1 is responsible for triggering cell growth and proliferation, as well as stimulating the growth of the bone, cartilage and connective tissues. The body makes a maximum production of IGF-1 between ages 18 to 25. The IGF-1 levels begin to decline after age 35. The growth of children peaks at 3 and is at its lowest levels in young adulthood.
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The IGF-1 is crucial for the body’s ability to heal and recover from injury, disease and/or surgery. It aids in the formation of bone and connective tissue, cell growth and proliferation, and the repair and maintenance of muscle tissue. IGF-1 assists in the healing of broken bones and soft tissue (muscle and skin). When a patient undergoes total knee or hip replacements, and especially if these surgeries involve the removal of the spleen, blood levels of IGF-1 are significantly reduced. The spleen is considered the “liver of the immune system.” (Gangwisch, 2007).
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If you are undergoing a total knee or hip replacement and you are losing blood during the procedure, ask your surgeon if the spleen should be removed with the knee or hip. The spleen contains white blood cells that assist in the destruction of germs and other foreign substances.
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The loss of blood during a surgical procedure also causes a loss of protein and IGF-1. The body tries to compensate for the blood loss by pulling IGF-1 out of the bloodstream to maintain and keep up with muscle and tissue growth. If the surgical procedure has involved a large volume of blood and tissue loss, the body may not be able to compensate and the IGF-1 will be low for a significant length of time. In this situation, even though the patient is able to get up from the operating table and walk around the room, it can be months before IGF-1 levels have come back up to normal.
WHAT DOES IGF-1 DO?
The IGF-1 affects the healing of injured tissues and muscles in all parts of the body. It contributes to the growth of bones, cartilage and connective tissue.
IGF-1 acts like a hormone, stimulating the growth of cells and blood vessels. It stimulates the movement and repair of broken or damaged tissue. It also stimulates the production of red blood cells and white blood cells.
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The IGF-1 triggers a cascade of biochemical reactions leading to the repair of damaged tissue. The IGF-1 can even work in concert with the body’s natural ability to heal damaged tissue.
The IGF-1 also affects the development of organs. IGF-1 acts as a hormone in many cells, including liver, spleen, skeletal muscles, heart, lungs, skin, testes and thyroid gland.
The IGF-1 aids in the repair of broken bones and soft tissue (muscle and skin) and the growth of cartilage and connective tissue (muscle and bone).
IS THERE A REASON WHY SOME PATIENTS CANNOT BUILD THEIR BLOOD LEVELS?
There are several factors that can cause a patient to have a low IGF-1 level and these can include the following:
• A high-protein diet (e.g., vegetarian diets)
• The body cannot produce an adequate amount of IGF-1 for the needs of healing and healing
• A patient has undergone a recent total knee or hip replacement and/or a major operation, especially one involving a large volume of blood and tissue loss
• If the blood is being aggressively transfused during the surgery, thus losing a large amount of blood and blood protein and IGF-1
• The liver, spleen or kidneys are diseased
• There is chronic diseases that interfere with the production and release of IGF-1
DIFFERENT THERAPEUTIC APPROACHES FOR MEALS AND SUPPLEMENTS
• Growth Hormone (GH):
A study by Goyal et al. (2008) demonstrated that the addition of GH to a total joint replacement (TJR) surgery may significantly improve postoperative outcomes (including postoperative wound healing and range of motion).
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These authors compared results from a group of 32 patients who underwent THR or TKR (tibial plateau leveling osteotomy with or without femoral and/or patella resurfacing) with GH (4 ug/kg/day, sc. 6 times a week) and a control group that received no GH.
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An improvement in postoperative wound healing was noted in the GH group when compared to controls.
DIFFERENT THERAPEUTIC APPROACHES FOR MEALS AND SUPPLEMENTS
Growth Hormone (GH): A study by Goyal et al. (2008) demonstrated that the addition of GH to a total joint replacement (TJR) surgery may significantly improve postoperative outcomes (including postoperative wound healing and range of motion). These authors compared results from a group of 32 patients who underwent THR or TKR (tibial plateau leveling osteotomy with or without femoral and/or patella resurfacing) with GH (4 ug/kg/day, sc. 6 times a week) and a control group that received no GH. An improvement in postoperative wound healing was noted in the GH group when compared to controls. The authors conclude that the addition of GH supplementation to these surgeries could improve outcomes, but further research is necessary to substantiate this claim.
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• Corticosteroids (Prednisone): The steroid, corticosteroids, inhibits IGF-1 synthesis and release by the liver. It is most commonly used to treat immune and inflammatory disorders (e.g., arthritis) and diseases that affect the lung (e.g., asthma).
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• Anti-Viral Drugs: The growth factor inhibitor, PegIFN-alfa, inhibits the growth and replication of most viruses. It is used to treat hepatitis B and hepatitis C. Anti-viral drugs can be used in combination with bone healing products, especially with the use of IGF-1.