All products on this site are for In-Vitro Research, Development use only. Products are Not for Human consumption of any kind. All products on this site are for In-Vitro Research, Development use only. Products are Not for Human consumption of any kind.
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Buy Hexarelin

Buy Hexarelin today for education and researchbuy hexarelin into new medical treatments. Hexarelin is available in 2mg and 5 mg vials for use in development and finding new pharmaceuticals. We want you to buy Hexarelin from a reputable source so for those in the research and science community. So choose us today to buy Hexarelin peptide!

What is Hexarelin used for?

Hexarelin is a potent, synthetic, peptidic, orally-active, centrally-penetrant, and highly selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) and a growth hormone secretagogue. It stimulates the secretion of growth hormone (GH) and stimulates appetite in both humans and rodents. It’s anabolic and orexigenic effects have made it an interesting substance for treating metabolic diseases and anorexia nervosa. It is currently under clinical development in a number of conditions in which the loss of lean body mass is a problem. In this review, we discuss the pharmacology, pharmacokinetics, efficacy, and safety of Hexarelin in humans. We also discuss the possible mechanism of action of Hexarelin.

Is Hexarelin a GHRH?

Hexarelin, a peptidyl analog of growth hormone secretagogue-1a (GHS-1a), is a synthetic growth hormone secretagogue that stimulates the secretion of GH, an effect that is mediated via a specific binding site on the growth hormone secretagogue receptor (GHRH). Growth hormone secretagogue (GHS)-1a is a cyclic peptide (GH~3~–GHS–NH~2~) that binds and activates the same receptor as ghrelin, a 28-amino acid hormone secreted by the stomach that stimulates the secretion of growth hormone (GH) and appetite. GHS-1a is an endogenous peptide that was initially identified as a circulating factor in the rat that stimulated the secretion of growth hormone (GH) (Kojima et al., 2001).

Later, Kojima et al. (2004) characterized a partial GHS-1a gene from the human hypothalamus and characterized a human ghrelin receptor (GHSR) that was highly homologous to the rat ghrelin receptor.

In addition, they reported the presence of the same GHS-1a gene in human pancreatic islets, suggesting that this peptide may be synthesized in the pancreas and/or in the gastrointestinal tract. Subsequently, this molecule was described in fish (Zwahlen et al., 2004).

What is the Chemical structure of Hexarelin?

The ghrelin receptor belongs to a new class of G protein-coupled receptors, which are known to mediate the secretion of GH. This receptor is located primarily in the hypothalamus and pituitary and is expressed in the arcuate nucleus, medial hypothalamus, and ventromedial nucleus. The ghrelin/GHSR system is involved in the regulation of energy balance and it was first identified in rats (Kojima et al., 2001), later in mice (Pelleymounter et al., 2002), and more recently in humans (Schuelert et al., 2002). In a series of studies using a variety of receptor subtypes and cellular signaling pathways, it was confirmed that ghrelin has a potent orexigenic effect in the brain by acting on several sites, including the arcuate nucleus (ArcN) and the ventral tegmental area (VTA). It also stimulated the release of growth hormone (GH) and stimulates feeding behavior by activating neurons in the ArcN, which may be related to the regulation of the synthesis and release of other substances in the hypothalamus.

What peptides are like HGH?

Ghrelin and GHS-1a interact with the same receptor (ghrelin receptor), which is highly homologous to the binding site of the endogenous ligand, ghrelin. It is the only peptidyl receptor described so far that does not contain a cysteine residue, unlike most receptors. In addition, the ghrelin/GHSR interaction activates signaling pathways different from the typical receptor-ligand interaction. These data indicate that this receptor is a special member of the G protein-coupled receptor family, called a selective receptor. The binding of ligands to this receptor may affect the activation of multiple receptors such as P2X purinoceptors, opioid receptors, and the adenosine-1 receptor.

Are peptides illegal?

In mice, the expression of the GHSR gene and its peptide ligand was found in the pituitary, ArcN, and VTA. GHS-1a, a synthetic peptidyl agonist of the GHSR, is a highly selective ligand with a 1000-fold greater potency than ghrelin in stimulating the secretion of growth hormone (GH) and inducing food intake in rats. In addition, GHS-1a is an efficient GH secretagogue in human adipose tissue, whereas ghrelin did not stimulate the secretion of GH in human adipose tissue (Tschöp et al., 2004). These data indicate that GHS-1a and ghrelin function by binding to the same receptor and activating distinct pathways. GHS-1a has a unique pharmacological profile that is unlike that of ghrelin. Both GHS-1a and ghrelin have the same primary amino acid sequence (GH~3~–GHS–NH~2~).

Purchase Peptides for Research

However, there are some differences in the amino acid sequences of these peptides in the C-terminus region, making these two peptides not identical. The peptides differ only in the replacement of Tyr (Tyr-3), by Phe (Phe-3) in GHS-1a, in addition to a Glu/Asp exchange in the hexarelin sequence (Phe-3–Glu–Lys–Asp–Tyr-3–His-5) in the hexarelin peptide. The GH-releasing properties of GHS-1a and its analogs, which do not include the Phe-3 sequence, have been investigated (Blevins and Kelly, 1994; Zwahlen et al., 2004). These studies indicate that the Phe-3 sequence and a positive charge are important for ghrelin\’s activity. Therefore, the Glu/Asp exchange in hexarelin (Phe-3–Glu–Lys–Asp–Tyr-3–His-5) may have contributed to the anabolic effects of hexarelin. Furthermore, a study in hypophysectomized rats (Cadet et al., 2004) found that GHS-1a can act in concert with other hypothalamic neuropeptides to enhance the secretion of GH. Thus, the hypothalamic peptides that have an anabolic effect, such as growth hormone-releasing hormone (GHRH), stimulate the synthesis of GHS-1a, which in turn stimulates the secretion of GH. Therefore, GHS-1a may function as a neurotransmitter that serves as a link between peptides and other brain cell types.

Buy Hexarelin for Research only

The GHSR is a member of the class B group of the rhodopsin-like family of G protein-coupled receptors, a class that includes the secretin receptor, β~2~ adrenergic receptor, and muscarinic acetylcholine receptors. This group of receptors is characterized by a seven-transmembrane domain structure, a relatively long extracellular loop and an intracellular loop. A number of important structural features of the GHSR allow its activation by ghrelin or GHS-1a (Kojima et al., 2004; Wurtman et al., 2004). These structural elements include the C-terminal sequence of the receptor, its relatively long extracellular loop, its intracellular loop, and the first two transmembrane domains. In addition, specific substitutions of amino acids are located in the loops.

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Gonadorelin For Sale

Gonadorelin For Sale here today for educational and research use only.Gonadorelin For Sale

Is Gonadorelin a peptide?

Gonadorelin is a research peptide that is the same as gonadotropin-releasing hormone (GnRH) that is naturally released from the hypothalamus gland. GnRH causes the pituitary gland to release other hormones (luteinizing hormone [LH] and follicle-stimulating hormone [FSH]). LH and FSH control development in children and fertility in adults. Gonadorelin helps fertility and helps with menopausal symptoms. It is used for women who have low estrogen levels, have a history of multiple abortions, and have not responded to previous hormone treatments.

Gonadorelin For sale as:

For more information about the medication, see PRECAUTIONS: PRECAUTIONS OF KNOWN EFFECTS, SPECIAL SENSITIVITY (ADVERSE REACTIONS), DRUG INTERACTIONS (ADVERSE REACTIONS), DRUG SIDE EFFECTS, and DOSAGE AND ADMINISTRATION.

How do you administer Gonadorelin?

For an oral tablet, an injectable, a topical ointment, or a topical vaginal ring, see FDA Product Information on Contraceptives and Hormone Replacement Therapy.

Tablets, Oral Solution, or Gel

Do not use it in pregnancy or during lactation. Female patients of childbearing potential should use effective contraception during treatment with this medicine and for at least 2 months after the last dose. Do not use it in children.

Gonadorelin Side Effects?

Drugs used in the treatment of endometriosis or polycystic ovary syndrome may cause serious adverse reactions when used with gonadorelin.

ADVERSE REACTIONS

Adverse reactions have been reported. Serious adverse reactions may be life-threatening and can include: blood clots, stroke, cardiovascular problems, and a condition called tumor lysis syndrome. Consult your doctor for more information.

PRECAUTIONS

Pregnancy

If a woman is planning to become pregnant or is pregnant, gonadorelin should be used only when clearly needed and strictly according to the instructions provided by your doctor. The safety of gonadorelin in pregnancy is not known. If used in a woman who is pregnant, gonadorelin may cause an abortion. Gonadorelin should be used with caution if there is a risk of miscarriage (loss of early pregnancy or spontaneous abortions). Gonadorelin is not indicated for the treatment of ovulation disorders or menstrual disorders. It is contraindicated for women with active, severe systemic lupus erythematosus, or when gonadorelin is used as a contraceptive.

Severe hypersensitivity to this drug has been reported. A severe allergic reaction, e.g., anaphylaxis, occurs in less than 1% of patients receiving gonadorelin. Closely monitor patients for symptoms of hypersensitivity during therapy with gonadorelin. Discontinue gonadorelin therapy if an allergic reaction occurs. Injections should be given using medical facilities equipped to deal with anaphylactic reactions.

Contraceptive Effects

Gonadorelin should be used to support fertility in a natural cycle only. Do not use it to prevent pregnancy (contraception). It should be used with caution in women of childbearing potential who do not wish to become pregnant. If you are a woman of childbearing potential (including adolescents), plan your pregnancy carefully. Do not assume that you will be pregnant because you are being treated with this drug. Consult your doctor if you are not certain of your pregnancy status (See PRECAUTIONS).

Do not use an injectable solution of gonadorelin for injection in women who are or plan to become pregnant. Gonadorelin is used only to support fertility. Do not use it to prevent pregnancy (contraception). It should be used with caution in women of childbearing potential who do not wish to become pregnant. If you are a woman of childbearing potential (including adolescents), plan your pregnancy carefully. Do not assume that you will be pregnant because you are being treated with this drug.

Ovulation Disorder

Use gonadorelin only to help women ovulate or to induce ovulation. Do not use to prevent pregnancy (contraception). Do not use this drug to support ovulation in women whose ovulation is not controlled by medications. If you are being treated for an ovulation disorder, you should follow your doctor’s instructions carefully. Do not increase the frequency of your menstrual periods.

Is there a High Risk of a Heart Attack?

Gonadorelin should be used only to help support fertility in women at high risk for a heart attack or who have a history of heart disease. Gonadorelin should be used with caution in women with a history of a previous myocardial infarction, angina, coronary bypass surgery, angioplasty, or stroke. Do not use gonadorelin in the following conditions:

  • Uncontrolled hypertension,
  • Myocarditis or cardiomyopathy (in patients with previous heart disease),
  • Sudden, unexplained, severe weakness,
  • Any disease that may lead to sudden cardiac arrest (e.g., ventricular tachycardia or cardiac arrest).

Gonadorelin For Sale and Important Safety Information

Interactions:

Do not use in combination with GnRH agonists, other gonadotropin-releasing hormones, GnRH analogs, or GnRH-receptor antagonists. The use of GnRH agonists and analogs, and GnRH antagonists may increase the risk of bone loss in women taking gonadorelin.

Caution is advised in patients with a history of diabetes, hypertension, cardiovascular disease, coronary disease, or in those with hyperlipidemia or a tendency to hyperlipidemia.

Use caution in patients with a history of heart disease or arrhythmias.

Take care when giving a dose of gonadorelin subcutaneously in women of childbearing potential.

Use caution in elderly patients, patients with a history of a recent heart attack or stroke.

Do not administer to women in labor, those with risk factors for the acute coronary syndrome, or patients with myocarditis, pericarditis, or unexplained prolonged QTc interval.

Take care with gonadorelin in patients with risk factors for cardiovascular disease (e.g., hypertension, hyperlipidemia), or a history of cardiovascular disease (e.g., coronary artery disease, myocardial infarction, angina, stroke, and transient ischemic attack).

Gonadorelin For Sale for research use only and is not for use on humans.

All products on this site are for In-Vitro Research, Development use only. Products are Not for Human consumption of any kind.