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How can I increase my GLP-1 naturally?

GLP-1 is secreted in response to nutrient ingestion and acts to reduce meal-associated glucose excursions through two distinct G-protein coupled receptors (Drucker, D J. “The Glucagon-like Peptide System”. Endocrine Reviews 15:427-502, 1994). GLP-1 binds to the GLP-1 receptor (GLP-1R) to elicit biological responses including stimulation of glucose-dependent insulin secretion, inhibition of glucagon secretion, appetite suppression, and enhanced gastric motility.

Is there any generic GLP-1?

A peptidyl-derivative of GLP-1, exendin-4, has a biological effect on reducing blood glucose levels in diabetics, consistent with its putative role as an endogenous ligand for the GLP-1 receptor. A randomized, placebo-controlled study of the effect of an analog of glucagon-like peptide-1 (7-36 amide) on glucose tolerance in patients with type 2 diabetes.

The GLP-1 receptor has been identified and pharmacologically targeted as a novel anti-diabetic therapeutic

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Exendin-4 is an agonist of the GLP-1R with high sequence homology (33%) with native GLP-1. Exendin-4 activates GLP-1R-mediated intracellular signals in the presence of endogenous ligand. Because of the homology in amino acid sequences between GLP-1 and exendin-4, exendin-4 is useful as an exogenous ligand of the GLP-1 receptor and is particularly suited as a probe of receptor-ligand interactions. The cAMP signaling pathways associated with the GLP-1 receptor are highly conserved.

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Binding of GLP-1 to the GLP-1R has been reported to increase cAMP in various cell types including insulinoma cells (Gimblet, R. et al. “Glucagon-like peptide-1 inhibits K+-induced insulin release in a glucose-dependent fashion”, Diabetologia 36: 689-697, 1993), gastric cancer cells (Jiang, Y. et al. “Increased expression of glucagon-like peptide-1 receptors in adenocarcinomas of human stomach”, Biochimica et Biophysica Acta 1490: 77-84, 2000) and insulin secreting cells (Ombrosi, D. et al.

GLP-1 stimulates insulin secretion by increasing the number of functional GLP-1 receptors in insulin secreting cells”, Biochem. Biophys. Res. Comm. 294: 953-961, 2002).

Is GLP-1 a peptide hormone?

GLP-1 and its analogs are a useful class of compounds to reduce blood glucose and increase insulin, an effect that has stimulated research on these peptides for the treatment of diabetes. GLP-1, however, has a short duration of action and is known to stimulate the release of glucagon from pancreatic α-cells.

Glucagon and its related homologs, glucagon-like peptides (GLP-2) and secretin, belong to the superfamily of secretin-related peptides (SRPs). GLP-2 is secreted by intestinal L-cells in response to nutrient ingestion and has a number of effects, including stimulation of gut growth, stimulation of exocrine secretion from the pancreas and gut, and modulation of glucose-induced insulin secretion.

An analog of GLP-2, Exendin-4, has been shown to delay gastric emptying in vivo.

GLP-1 dosing chart

Protease inhibitors are a class of compounds useful in the treatment of a variety of conditions involving aberrant proteolysis, including viral and autoimmune proteolysis. Examples of protease inhibitors include aprotinin, Trasylol, and other serine protease inhibitors and leupeptin, camostat, and other metalloprotease inhibitors.

Proteases are involved in the degradation of many peptides and proteins.

This biological activity is involved in many physiologic processes and is a contributing factor in many diseases and conditions. The term “protease” or “proteolytic enzyme” is used herein to mean any enzyme that catalyzes the hydrolysis of a peptide or protein. Such enzymes can be exopeptidases, i.e., those peptidases that act external to the polypeptide, or endopeptidases, i.e., those peptidases that act within the polypeptide.

An example of an endopeptidase is an aminopeptidase.

A summary of the amino acids most commonly cleaved and the enzymes (proteases) that catalyze the hydrolysis.