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How do you get TRH?
Thyrotropin TRH/LHRH (also called thyroliberin) is a hypothalamic neuropeptide that stimulates the thyroid release of T3 and T4 from the thyroid gland. It is similar in structure to LHRH [Luteinizing hormone-releasing hormone (LH-RH)] but its effects are less potent and it is more variable. It has a short half-life. TRH has no antisecretory activity, but stimulates, via its action on the pituitary, increased thyroid hormone output, particularly T3.
Is TSH and TRH the same?
Thyrotropin TRH (tripeptide hypothalamic regulatory hormone) is effective in regulating hormones concerned with the thyroid hormone. It is useful for treating patients with thyroid disorders. The first published description of this material and its therapeutic uses is found in U.S. Pat. No. 3,974,276 (issued to T. A. Waddell et al). According to this patent, thyroid hormones can be beneficially regulated by administering a TRH substance to a patient in a sufficient amount to achieve a desired therapeutic effect.
Further, it was shown that TRH is stable at room temperature and does not undergo significant changes in its activity at such temperatures. Thus, the TRH tripeptide may be delivered to the patient in a suitable composition containing an inert stabilizer to provide a “cold” injectable pharmaceutical preparation, the injection being “cold” since the patient’s body temperature is usually in the range of 37.degree. to 38. degrees. C.
What stimulates TRH?
The TRH composition is preferably isotonic with the blood or body fluid of the patient to be treated. However, in administering the TRH-containing composition to the patient, the TRH concentration should be sufficiently high to achieve a therapeutic effect, but sufficiently low so that metabolic breakdown of the TRH does not occur. TRH compounds have the property of exhibiting a sharp, discrete, breakpoint at about 0.5 ng/ml when assayed by the so-called “immuno-diffusion” technique on a Sephadex G-25 column. This breakpoint represents the concentration at which the TRH will be maximally effective. Thus, it is preferred that the TRH concentration in the composition be within this concentration range.
Does TRH cause weight gain?
Subsequent to the original TRH patent there has been some discussion and controversy regarding TRH as an endogenous hypothalamic TRH. For example, U.S. Pat. No. 3,906,220 to F. E. McManus shows that TRH-like peptides exist in the nervous system of humans, birds, and fish, and that such peptides are also produced in the anterior pituitary gland. The patent suggests that the function of such peptides is to provide a positive feedback control mechanism for the functioning of TRH systems. U.S. Pat. No. 3,928,572 to D. R. McDevitt et al shows that a “cold” injectable TRH is therapeutically effective to raise the plasma thyrotropin levels in humans and prevent thyroid atrophy, and is thus useful in treating thyroid disorders.
The patent shows a TRH composition wherein the TRH concentration is above the “therapeutic” break point concentration of about 0.5 ng/ml and is within the range of from about 1 ng/ml to about 100 ng/ml. This composition can be prepared from the crude TRH extract from the natural source, such as the hypothalamus of pigs, sheep and rats.