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BUY BPC 157 Peptide Introduction
It also shares homology with various antihypertensive peptides. Its biological functions are not clear, but experimental studies in vitro and in vivo have shown that it is a protective compound against oxidative stress (such as in atherosclerosis, hypertension and diabetes), and has anti-diarrheal and anticancer effects. It is the first anti-cancer protein in vitro to be clinically applied. This compound has certain biological properties. The use of an active substance, BPC 157, in the treatment of various diseases and for the development of drugs has been considered. There are ongoing clinical trials of human trials. In animal studies, it has been shown that BPC 157 can block the growth of cells with genetic changes and induce apoptosis.
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Current Clinical Trials of BPC 157
It is known that BPC 157 has a significant effect in reducing inflammation, which is common in patients with a series of diseases, such as hypertension, coronary heart disease, etc. The application of BPC 157 can inhibit the inflammatory reaction and promote ulcer healing. In recent years, many studies have shown that the mechanism of action of BPC 157 is closely related to macrophage apoptosis.
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In animal studies, BPC 157 has been found to affect various cells in the body, such as human colon cancer cells (HCT 116 and HT-29), human gastric cancer cells (MKN45), human prostate cancer cells (PC3), human lung cancer cells (A549), and mouse breast cancer cells (4T1). BPC 157 could promote the apoptosis of cancer cells, inhibit the growth of cells with genetic changes, and be effective in clinical cancer chemotherapy. Some studies have shown that BPC 157 may be able to induce other cancer cells death pathways, such as autophagy, necroptosis, and other apoptosis pathways. It can not only directly inhibit cancer cell growth, but also indirectly promote the proliferation of cells and inhibit apoptosis, thereby promoting the growth of normal cells and preventing side effects.
What are BPC-157 Benefits?
BPC 157 also has the potential to affect the immune response in cancer patients and to induce an anti-cancer effect. For example, BPC 157 can improve the overall immune function of cancer patients, protect normal tissue, activate the immune response of the body, improve the host immune function of the patient, and have a long-lasting therapeutic effect, but it is limited by poor transport and low bioavailability in the intestine, so it is difficult to enter and reach a therapeutic concentration in the human body. The main clinical treatment for cancer is surgery and chemotherapy, with an emphasis on surgery.
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On December 23, 2014, the U.S. FDA approved BPC 157 for clinical treatment in cancer, and it was also the first substance approved by the agency for cancer treatment.
BPC 157 was first isolated from the human stomach in 1988 and its molecular structure is based on a pentadecapeptide of human body origin. A human-derived pentadecapeptide, BPC 157, has a linear structure consisting of 15 amino acid residues, of which the first five residues are located on the C-terminus, while the remaining 10 residues are located on the N-terminus.
Structure of BPC 157
The 15-amino acid-sequence BPC 157 consists of the following amino acids: Val, Ser, Pro, Arg, Thr, Ser, Asn, Asp, Gly, Leu, Asp, Val, Lys, Ile, Phe, Leu, Thr. They are arranged in the following order: C-terminal (5 amino acids), middle (4 amino acids), and N-terminal (10 amino acids) segments.
BPC-157 Reviews
BPC 157 is a penta-decapeptide that can exert a variety of biological activities and exhibit a broad range of pharmacological activities. The main properties of BPC 157 are as follows: (1) BPC 157 exerts beneficial effects on various diseases and promotes the body’s physical and mental health, and (2) it has anti-hypertensive and antioxidant properties, thus can delay or prevent cardiovascular disease, diabetes, and cancer.
Effect of BPC 157 on Hypertension
Many studies have shown that BPC 157 can effectively treat hypertension. In patients with normal blood pressure (BP), there were no significant changes in the levels of blood pressure after BPC 157 administration \[[@B4-toxins-11-00573]\], and the results of the study by Nohrstedt et al. showed that after six weeks of BPC 157 administration, blood pressure in patients with mild and moderate hypertension was reduced. When the dose of BPC 157 was increased, the anti-hypertensive effect could be better. Therefore, BPC 157 is a safe and effective drug for the treatment of hypertension.
Effect of BPC 157 on Cardiovascular Disease
In patients with hypercholesterolemia, BPC 157 has no effects on plasma levels of lipid metabolism indices (total cholesterol, low-density lipoprotein cholesterol, and triglycerides) and blood pressure. Another study showed that the body’s fat oxidation index and cholesterol levels in the body are significantly increased, and the levels of atherosclerosis indicators (total cholesterol and triglycerides) in the blood are significantly reduced.